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- Title
Immunoregulatory Effects of Sanguis Draconis Flavones on Mouse Spleen Lymphocytes.
- Authors
Dewu JIA; Dongrui XU; Deyun JIA; Rui LI
- Abstract
[Objectives] This study aimed to study the effects of Sanguis Draconis flavones( SDF) on the immune regulation of mouse spleen lymphocytes. [Methods]A total of 60 BALB/c male mice were evenly and randomly divided into normal control group, model group, positive group, and high, middle and low-dose SDF groups. The mice in the model group were injected intraperitoneally with cyclophosphamide to establish mouse immunosuppressive model. The mice in the other groups were intragastrically administered at the respective doses, and the body weight was weighed once a week during the administration period. After 30 d of administration, the thymus and spleen indexes, the spleen lymphocyte proliferation ability, the NK cell activity, and the IL-2, IL-4 and INF-γ contents in the culture supernatant were measured. [Results] SDF could significantly increase the thymus and spleen indexes and improve the spleen lymphocyte proliferation ability and NK cell activity of the mice, as well as increasing the IL-2 and INF-γ contents and reducing the IL-4 content in spleen lymphocyte suspension culture. [Conclusions] SDF have good immunoregulatory effect.
- Publication
Medicinal Plant, 2019, Vol 10, Issue 3, p49
- ISSN
2152-3924
- Publication type
Academic Journal
- DOI
10.19600/j.cnki.issn2152-3924.2019.03.012