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- Title
Evaluation of the hepatoprotective effects of rumex acetosella on the carbon tetrachloride-induced hepatotoxicity in rats.
- Authors
Nejad, Zarrin Sarhady; Bamakan, Ali Mandegary; Sharfififar, Fariba; Mokhtari, Saeedeh; Iranpour, Maryam
- Abstract
Objectives: Medicinal herbs have long been used for the treatment of hepatic disorders. Rumex acetosella is one of the plants used for this purpose in the Iranian traditional medicine. This study aimed to investigate the protective effects of Rumex acetosella against the hepatotoxicity induced by carbon tetrachloride (CCl4) in rats. Materials and Methods: In this study, 64 albino Wistar rats were divided into 8 groups. Groups I-IV were considered as control and received normal saline (I and III) and vehicle (II and IV). Groups V-VIII received 250, 500, 750 and 1500 mg/kg of Rumex acetosella, respectively through gavage for 14 days. On day 15, groups III-VIII received one ml/kg of CCl4 1:1 in olive oil via intraperitoneal injection. Animals were killed 48 hours after CCl4 injection, and their liver and blood samples were collected to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) for histopathological examinations and antioxidant status. Acute organ toxicity of the formulation was evaluated by measuring the blood cell count, liver marker enzymes, creatinine, antioxidant status and histopatological examinations in all groups. Results: According to the histopathological examinations, Rumex acetosella had dosedependent effects on the reduction of serum levels of ALT, AST and ALP. Moreover, pretreatment with Rumex acetosella decreased lipid peroxidation, while maintaining the levels of glutathione and total antioxidant capacity. However, no significant effects were observed on the hematotoxicity and hepatotoxicity of the rats until Rumex acetosella treatment at the dose of 1500 mg/kg. Conclusion: According to the results of this study, long-term use of Rumex acetosella leads to no side effects in any of the body organs. Therefore, this medicinal plant could be used against hepatic damages induced by xenobiotics. It is recommended that future studies be conducted on different models of hepatic injury as to find the exact hepatoprotective mechanisms of Rumex acetosella.
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p134
- ISSN
2228-7930
- Publication type
Academic Journal