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- Title
DESIGN AND OPTIMIZATION OF DEXAMETHASONE MATRIX TABLETS FOR THE TREATMENT OF INFLAMMATION IN COLON CANCER.
- Authors
Sharma, Ankush; Kanwar, Kapil
- Abstract
The purpose of the present study was to prepare & characterize the colon targeted matrix tablet of dexamethasone for treatment and management of inflammation in colon cancer. The matrix tablet was prepared by wet granulation method. The matrix tablet was then coated with different concentration of shellac solution by dip coating method to prevent drug release in stomach. The prepared matrix tablets were evaluated for hardness, weight variation, friability and (in-vitro) dissolution. The in-vitro drug release of different formulation was found to be minimum 84.84±2.16 and maximum 99.41 ±0.96. The formulation F5 shows best result in in-vitro drug release.
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2014, Vol 4, Issue 4, p906
- ISSN
2249-9504
- Publication type
Academic Journal