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- Title
Combined Clopidogrel And Aspirin Treatment Up To Surgery Dosen't Increase The Risk Of Postoperative Blood Loss And Reoperation For Bleeding In Patients Undergoing Coronary Artery Bypass Grafting.
- Authors
Heidari, Amanollah; Dezfouli, Fatemeh Ghalambor; Tabatabi, Kamalodin; Mali, Shahriar; Ahang, Ramin; Latifi, Seyd Mahmood; Sheikhi, Mohammad Ali
- Abstract
Dual antiplatelet therapy is widely used in patients with coronary artery disease and the optimal management of aspirin and clopidogrel before surgery in patients with acute coronary syndrome is uncertain. The study was a prospective and randomized trial .Patients undergoing urgent coronary artery bypass graft surgery (CABG) were randomly assigned to one of two groups . Group A of patients operated by an experienced surgeon . Group B of patients that treated precautionary by blood products operated by two recently graduate surgeons . Simultaneously one group of elective patients operated after 5 days of antiplatelet cessation by mentioned experienced surgeon (Group C). Randomly assigned patients were 150 adults whom 50 in each group .The total units of given packed red cell ; fresh frozen plasma and platelets in groups of A, B and C were (0.78± 1.14 ; 3.60 ±2.20 ; 3.14 ± 1.90 ; P < 0.0001 - 0 ± 0 ; 5.20 ± 3.40 ; 2.34 ± 2.36 ; P < 0.0001 and 0 ± 0 ; 2.10 ± 4.90 ; 0.06 ± 0.42 ; p < 0.005 respectively ) . The amount of bleeding in that order was (987 ± 443 ml ; I2I0 ± 830.30 ml ; 973 ± 537.50 ml ; p< 0.204 ) No re-exploration was found in groups A and C while 4 case of group B returned to operating room for control of bleeding and tamponade (8%). Precise CABG with good hemostasis by experienced surgeons can reduce requirement of blood products and bleeding in patients undergoing primary urgent CABG without clopidogrel and aspirin cessation.
- Publication
International Journal of Pharmaceutical Research & Allied Sciences, 2016, Vol 5, Issue 3, p164
- ISSN
2277-3657
- Publication type
Academic Journal