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- Title
EFFECTS OF ROSMARINUS OFFICINALIS ESSENTIAL OIL IN MEMORY FORMATION AND RELIEVING BRAIN OXIDATIVE STRESS IN ZEBRAFISH MODEL.
- Authors
CAPATINA, LUMINITA; TODIRASCU-CIORNEA, ELENA; NAPOLI, EDOARDO; HRITCU, LUCIAN
- Abstract
This study was done to assess the anxiolytic, anti-amnesic and antioxidant potential of Rosmarinus officinalis essential oil, in three concentrations 25, 150 and 300 ml / L. Anxious behavior and memory performance were assessed by NTT (new tank diving test) and Y and T mazes, and scopolamine (100 μM) was administered by immersion 30 minutes before behavioral testing to induce anxiety and a mild dementia. Our data has shown that essential oil of rosmarin has diminished anxious behavior and amnesia induced by the use of scopolamine in parallel with the decrease in oxidative stress in the zebra fish brain. The essential oil of rosmarin is known for its anti-inflammatory effects due to its compounds - α-pinene, camphor, eucalyptol - the chemical composition being identified by GC-MS. At the same time, literature mention the anti - amnesic and anti - acetylcholinesterase effects of rosemary essential oil in a scopolamine - induced Wistar rat animal model. The results obtained from the behavior of zebrafish behavior in the three behavioral tests show a significant difference between the activity of scopolamine-treated animals and those exposed to rosmarin oil, especially in the concentration of 25 μl / L. In conclusion, the essential oil studied could be considered a good candidate for improving memory by inhibiting acetylcholinesterase and reducing oxidative stress in the brain.
- Publication
Journal of Experimental & Molecular Biology, 2019, Vol 20, Issue 3, p29
- ISSN
2601-6974
- Publication type
Academic Journal