We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-tailed Macacque: A Pilot Study.
- Authors
Uno, Hideo; Zimbric, Michele L.; Albert, Daniel M.; Stjernschantz, Johan
- Abstract
Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 μg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 μg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty μg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 μg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.
- Publication
Acta Dermato-Venereologica, 2002, Vol 82, Issue 1, p7
- ISSN
0001-5555
- Publication type
Academic Journal
- DOI
10.1080/000155502753600803