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- Title
EVALUATION OF ANTIBACTERIAL ACTIVITY 5-AMINO-3-METHYL-ISOXAZOLE-4-CARBOHYDRAZIDE AND 5-AMINOISOXAZOLO[5,4-d]PYRIMIDIN-4-ONE DERIVATIVES.
- Authors
MĄCZYŃSKI, MARCIN; REGIEC, ANDRZEJ; PŁOSZAJ, PAULINA; KAČÁNIOVÁ, MIROSLAVA; PIWOWAR, AGNIESZKA
- Abstract
Searching for new compounds with specific biological activity in relation to various bacterial strains due to the increasing number of bacterial infections and the frequently developing antimicrobial resistance (AMR) is a significant problem in healthcare. Based on previous promising research related to the activity of isoxazole-4-carbohydrazide derivatives, we currently examined different substituted isox-azole-4-carbohydrazide derivatives in vitro against a panel of bacterial strains. In this work, we evaluated the antibacterial activity of 30 derivatives, previously described as mildly antimycobacterial, in 10 bacterial strains (5 Gram-negative (G-) and Gram-positive (G+) bacterias). Based on minimum inhibitory concentration (MIC), mainly MIC50 and MIC90 values, the tested derivatives generally have shown rather weak and mild antibacterial activity. The most active compounds were 3d and 4d, both with methyl sub-stituents in the benzene ring. A more detailed examination should be continued but this research increased the library of isoxazole derivatives with broad biological activity.
- Publication
Acta Poloniae Pharmaceutica, 2023, Vol 80, Issue 1, p79
- ISSN
0001-6837
- Publication type
Academic Journal
- DOI
10.32383/appdr/162790