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- Title
Relation of Lactoferrin Levels in Gastric Mucosa with Helicobacter pylori Infection and with the Degree of Gastric Inflammation.
- Authors
Nakao, Kazuyuki; Imoto, Ichiro; Ikemura, Norihisa; Shibata, Tomoyuki; Takaji, Satoshi; Taguchi, Yukiko; Misaki, Moriharu; Yamauchi, Koji; Yamazaki, Natsuko
- Abstract
Objectives: Lactoferrin (Lf) is an iron-binding glyco-protein present in milk, lacrimae, saliva, and gastroduodenal secretions. <em>In vitro</em> studies disclosed contradicting results regarding the relation of Lf with <em>Helicobacter pylori (HP)</em> infection. This study aimed to investigate the relationship between the gastric mucosal concentration of Lf and <em>HP</em> infection of the stomach. The relationship of the gastric mucosal level of Lf with the gastric mucosal concentration of interleukin-8 (IL-8) and with the intragastric ammonia levels was also assessed. In addition, the gastric mucosal Lf levels before and after irradication of <em>HP</em> infection were also evaluated. Methods: This study was composed of 27 <em>HP</em>-positive and 12 <em>HP</em>-negative patients with chronic gastritis. Gastric mucosal biopsy specimens were obtained from all subjects by endoscopy, and the degree of histological inflammatory changes were assessed according to the Sydney system. The gastric mucosal levels of Lf and IL-8 were measured by immunoassays. Assessment of the effect of therapy on the gastric mucosal level of Lf was performed in 10 patients with <em>HP</em>-associated duodenal ulcer. Results: Lf, 1L-8, and ammonia levels were significantly higher in patients with <em>HP</em>-positive gastritis compared with those with <em>HP</em>-negative gastritis in both the antrum and the gastric body. Histologically, the degree of inflammatory changes correlated significantly with the Lf levels in the gastric mucosa. Furthermore, the degree of <em>HP</em> colonization was more significant in biopsy samples from the antrum than in those from the corpus of the stomach. The gastric mucosal levels of Lf and IL-8 correlated significantly in the antrum and the gastric body. The ammonia intragastric level significantly correlated with the mucosal Lf level in the antrum and in the gastric body. Therapy significantly decreased the Lf levels in the gastric mucosa of the...
- Publication
American Journal of Gastroenterology (Springer Nature), 1997, Vol 92, Issue 6, p1005
- ISSN
0002-9270
- Publication type
Academic Journal