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- Title
Transfusion-Related Chronic Liver Disease in Sickle Cell Anemia.
- Authors
Comer, Gail M.; Ozick, Lisa A.; Sachdev, Ranjit K.; Kumar, Sudhir; Taunk, Jawahar L.; Smith, Jeanne A.; Tai-Ping Lee; Clain, David J.
- Abstract
The medical records and liver biopsies of nine sickle cell patients with chronically elevated fiver function tests were retrospectively reviewed to determine the etiology of chronic liver disease. There were eight women and one man with a mean age of 30 yr. All patients had hemoglobin SS. Eight patients were referred for elevated aminotransferases and one for an elevated alkaline phosphatase. Hemosiderosis was present in all of the biopsies. Two patients had cirrhosis. Chronic hepatitis was noted in two patients, and five patients had cholestasis. Two patients had serologic markers demonstrating HBV exposure but no patients were HBsAg positive. Erythrophagocytosis, sinusoidal dilatation, and Kupffer cell hyperplasia were present in all of the fiver biopsies. Transfusion-related causes were the most common significant pathologic findings in our patients, and appeared to be the etiologies of chronic fiver disease in sickle cell patients.
- Publication
American Journal of Gastroenterology (Springer Nature), 1991, Vol 86, Issue 9, p1232
- ISSN
0002-9270
- Publication type
Academic Journal