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- Title
Effect of Somatostatin on Exocrine Pancreas Evaluated on a Total External Pancreatic Fistula of Neoplastic Origin.
- Authors
Roncoroni, Luigi; Violi, Vincenzo; Montanari, Marzio; Muri, Maurizio
- Abstract
A patient with a pancreatic fistula, with a defunctionalized duodenum (subsequent to a previously performed Billroth II gastrectomy for cancer and choledochojejunostomy for metastatic infiltration in the bile duct) was submitted to prolonged synthetic somatostatin infusion (48 h). There was a mean reduction of 80% in pancreatic output, with no changes in the composition of sodium, potassium, and calcium, an increase in chloride and a decrease in bicarbonate. An increase in amylase was noted. The unique clinical features of this case have provided direct confirmation of the inhibiting action of somatostatin on the exocrine pancreas.
- Publication
American Journal of Gastroenterology (Springer Nature), 1983, Vol 78, Issue 7, p425
- ISSN
0002-9270
- Publication type
Academic Journal