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- Title
High Prevalence of Celiac Disease among Patients with Insulin- Dependent (Type I) Diabetes Mellitus.
- Authors
Cronin, Cornelius C.; Feighery, Aisling; Ferriss, J. Barry; Liddy, Caroline; Shanahan, Fergus; Feighery, Conleth
- Abstract
Objectives: Diagnosis of unrecognized celiac disease is potentially important. The prevalence of celiac disease in patients with insulin-dependent diabetes mellitus is uncertain. We report the prevalence of celiac disease in a stratified random sample (n = 101) of adult insulin-dependent diabetic patients (age, 18-59 yr) attending our clinic, and in an age- and sex-matched control group (n = 51). Methods: Screening was by anti-endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord. Results: Celiac disease had not been suspected in any patient at the time of screening. Eight patients tested positive for anti-endomysial antibody, all of whom had a distal duodenal biopsy performed. Five patients had histologic evidence of celiac disease. One patient with negative histology was receiving immunosuppressive therapy for a renal-pancreas transplant. Of the five patients with abnormal histology, two improved on gluten restriction, one was unable to comply, one refused treatment, and one was lost to follow-up. No control subject tested positive for endomysial antibody. Conclusions: Patients with insulin-dependent diabetes have an increased prevalence of celiac disease. Because most cases are clinically unrecognized, consideration should be given to screening all insulin-dependent diabetes mellitus patients with endomysial antibodies.
- Publication
American Journal of Gastroenterology (Springer Nature), 1997, Vol 92, Issue 12, p2210
- ISSN
0002-9270
- Publication type
Academic Journal