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- Title
THE PHARMACOLOGY OF TRYPTAMINE.
- Authors
Reid, G.
- Abstract
In the eat and the dog and the rabbit tryptamine causes a rise of systemic arterial pressure which is occasionally preceded or followed by a fall. These effects can be seen when the vagus nerves are intact or divided. In the dog and eat and to a slighter degree in the rabbit there is also a rise of pressure in the pulmonary artery or right ventricle. The pressor response in each circulation is reduced by yohimbine. The rise of systemic arterial pressure in the eat and dog is due to a direct vasoconstrictor action (demonstrated in the hind limb) and to a dynamic effect on the heart. In the dog the initial fall is due to pulmonary vasoconstriction and the secondary fall possibly to coronary vasoconstriction. The outflow from the coronary sinus in the dog is increased during the dynamic action of the heart following which the outflow may decrease for some minutes. The action of tryptamine on the kidney (cat) is weak or absent compared with its effect in the hind limb. The portal pressure in the dog is raised by the systemic intravenous injection of tryptamine. This is not due to constriction of the hepatic sphincter but appears to be a passive result of the raised arterial pressure. The drug causes a brief period of apnoea in the cat which is not observed after vagal division. It also causes bronchoconstriction. Muscular twitching and evacuation of the bladder were also observed in the cat. When injected into the arterial supply of the suprarenal glands tryptamine does not liberate adrenaline. It contracts the nictitating membrane of the cat, this action and the similar action of cat serum being sensitized by denervation and depressed by yohimbine. The response of the innervated membrane is sometimes sensitized to both serum and tryptamine, by benadryl or cocaine. The pupil of the cat dilates transiently and then constricts strongly to tryptamine and serum. Th drug stimulates isolated arterial strips, the rat uterus and the guinea-pig intestine...
- Publication
Australian Journal of Experimental Biology & Medical Science, 1951, Vol 29, Issue 2, p101
- ISSN
0004-945X
- Publication type
Academic Journal
- DOI
10.1038/icb.1951.13