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- Title
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL Correspondence.
- Authors
Sportoletti, Paolo; Baldoni, Stefano; Cavalli, Laura; Del Papa, Beatrice; Bonifacio, Elisabetta; Ciurnelli, Raffaella; Bell, Alain Sylvin; Di Tommaso, Ambra; Rosati, Emanuela; Crescenzi, Barbara; Mecucci, Cristina; Screpanti, Isabella; Marconi, Pierfrancesco; Martelli, Massimo F.; Di Ianni, Mauro; Falzetti, Franca
- Abstract
The article offers information on the advancement in the process of diagnosis, prognosis, and treatment of B-cell chronic lymphocytic leukaemia (B-CLL). It mentions that high expression of zeta-chain-associated protein kinase 70 (ZAP-70) and unmutated immunoglobulin heavy variable (IGHV) genes are considered poor factors for prognosis. It informs that NOTCH1 and PEST mutations are considered as marker of poor prognosis in a minority of B-CLL patients.
- Publication
British Journal of Haematology, 2010, Vol 151, Issue 4, p404
- ISSN
0007-1048
- Publication type
Academic Journal
- DOI
10.1111/j.1365-2141.2010.08368.x