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- Title
Aerobic Exercise Training Reverses Diastolic Dysfunction in Uncomplicated Well-Controlled Type 2 Diabetics.
- Authors
Brassard, Patrice; Legault, Sylvie; Garneau, Caroline; Bogaty, Peter; Dumesnil, Jean G.; Poirier, Paul
- Abstract
Aerobic exercise training increases exercise capacity in patients with type 2 diabetes but diastolic dysfunction is frequently encountered in these patients. The purpose of this study was to evaluate the impact of aerobic exercise training on diastolic dysfunction and exercise capacity in patients with uncomplicated well-controlled type 2 diabetes. Twenty-three sedentary subjects free of coronary disease with type 2 diabetes and diastolic dysfunction participated in the study. Subjects were treated with oral hypoglycemic agents and/or diet. Eleven subjects (EX) (age: 58±5 y; mean±SD) performed a 3-month aerobic exercise training using a cycle ergometer whereas a control group (CONT) of 12 subjects (57±6 y) maintained daily living activities. Exercise capacity and left ventricular diastolic function using echocardiography were evaluated before and after the 3-month exercise training program. At baseline, anthropometric data were similar between the groups except for body mass index (BMI) that was higher in the CONT group (31±3 vs. 28±3 kg/m²; p<0.05). There were also no significant difference in terms of metabolic control (HbA[sub 1c]: 6.4±1.2 vs. 5.8±1.3%; p=0.22) and maximal oxygen uptake (26.7±5.9 vs. 28.6±3.9 ml⋅kg[sup -1]⋅min[sup -1]; p=0.39) between the groups. Reversal of diastolic dysfunction to a normal function was observed in 5 out of 11 subjects (p<0.01) following exercise training. No change in diastolic function was observed in the CONT group. Maximal oxygen uptake increased in the EX group following exercise training (28.6±3.9 vs. 32.7±5.7 ml⋅kg[sup -1]⋅min[sup -1]; p<0.05) while there was no change in the CONT group (26.7±5.9 vs. 27.3±6.2 ml⋅kg[sup -1]⋅min[sup -1]; p=0.58). There were no significant change in BMI in the EX (p=0.46) and CONT (p=0.97) groups. Exercise training had no beneficial impact on metabolic control. In conclusion, these results suggest that aerobic exercise training improves diastolic dysfunction in subjects with type 2 diabetes.
- Publication
Diabetes, 2007, Vol 56, pA277
- ISSN
0012-1797
- Publication type
Academic Journal