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- Title
Improvements in Insulin Resistance with Weight Loss and Exercise Are Attenuated by Subclinical Hypothyroidism.
- Authors
Amati, Francesca; Dube, John J.; Stefanovic-Racic, Maja; Toledo, Frederico G.; Goodpaster, Bret H.
- Abstract
Weight loss and exercise-induced improvements in insulin resistance OR) am variable; some individuals experience robust enhancements in insulin sensitivity, while others do not. Thyroid hormone status is related to IR, but it is not clear whether subclinical hypothyroidism may help to explain the variability in improvements in IR. The purpose of this study was to examine the association between thyroid hormone status and the improvement in IR following exercise training in impaired glucose tolerant (IGT) subjects. Ten overweight to obese (BMI= 32 ±2.8 kg/m²) older (age=66.5±4.4 years) subjects completed a 16-week program consisting of 3-5 days per week, 30-45 min per session of moderate aerobic exercise (mostly walking). Insulin sensitivity, determined by a euglycemic hyperinsulinemic clamp, was measured before and after the intervention. A retrospective nested case control analysis was performed in subclinical hypothyroid (hypothyroid; N=5, TSH 4.38 ± 1.09 uIU/ml) versus normal thyroid (enthyroid; N=5, TSH 1.93 ±32 uIU/ml) subjects, matched on gender (3 women and 2 men in each group) and BMI. A 2x2 mixed ANOVA was performed on insuli a significant amount of body weight (∼6%, P≤0.001). These data suggest that despite a similar exercise program and weight loss, subclinical hypothyroidism may interfere with beneficial adaptations on muscle metabolism that typically occur with lifestyle modification. Further studies are needed to explore potential mechanisms that may underlie this blunted response in hypothyroid patients. ADA-Funded Research
- Publication
Diabetes, 2007, Vol 56, pA282
- ISSN
0012-1797
- Publication type
Academic Journal