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- Title
Multiple Anthropometric Parameters Associated to β-Cell Function in Normal and Diabetic Men.
- Authors
Milousis, Athanasios; Papachristou, Dimitrios N.; Katergari, Simoni A.; Mantatzis, Michalis; Asimakopoulos, Byron; Chalikias, Giorgos; Gioka, Theodora; Bounias, Ioannis; Christakidis, Dimitrios; Maltezos, Eustratios; Veletza, Stavroula; Prassopoulos, Panagiotis; Nikolettos, Nikos
- Abstract
To characterize fat accumulation and body fat distribution accurately in association to insulin secretion and action, 36 D (type II, BMI 31 ± 0,73 Kg/m²) and 30 N (BMI 30 ± 1,19 Kg/m²) male Caucasians underwent an oral glucose tolerance test (OGTT) and were studied, by the use of multiple methods appropriate to estimate fat. Fat accumulation and distribution was estimated by various conventional approaches (C-M) (Body weight, BMI, Waist, Hip and Thigh Circumference, Waist-to-Hip Ratio and % fat by Bioimpedance Analysis (BIA) as well as by Magnetic Resolution Imaging (MRI) application. For the abdomen and hip with multiple slices analyzed by a novel software. Insulin secretion was calculated by the insulin levels during OGTT as "area under the curve" (AUC). Insulin resistance was estimated by the Homeostasis Model Assessment (HOMA-R). No significant difference was observed between the 2 groups regarding all fat indexes, except BIA, which was found higher in D (30.91±3.88 vs 28.41±4.39%, p=0.017). D exhibited lower levels of AUC than N (355.79±312.01 vs 642.20±546.03 pmol/lt ⋅ min, p=0.014). AUC was not correlated to any of the fat indexes in both groups. The D exhibited higher HOMA compared to N (3.62±2.56 vs 1.46±0.89, p<0.01). Strong correlations of HOMA with both C-M and MRI subcutaneous fat indexes, -M, were found. Among C-M used, BMI exhibited the strongest correlation with HOMA (r=0.507, p=0.002) in D. Of all the MRI-M, visceral fat measured at L2-L3 level exhibited the strongest correlation with HOMA (r=0.445, p=0.012) in D, whilst in N such correlation was observed with subcutaneous fat measured at the hip level (r=0.578, p=0.002). Conclusions: (1) insulin resistance in D cannot be interpreted by differences in the anatomic distribution of fat, but probably by differences in the fat function between D and N (2). MRI is a useful method to distinguish the various anatomical compartments of fat that can be related to metabolic parameters and to their changes in T2DM (3). Not only visceral fat but also subcutaneous fat is important for the development of insulin resistance in DM.
- Publication
Diabetes, 2007, Vol 56, pA343
- ISSN
0012-1797
- Publication type
Academic Journal