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- Title
Insulin Resistance Is Associated with Elevated Resting Energy Expenditure in Pre-Pubertal Children - A Longitudinal Study.
- Authors
Hosking, Joanne; Metcalf, Brad S.; Jeffery, Alison N.; Gardner, Daphne S.; Voss, Linda D.; Wilkin, Terence J.
- Abstract
Resting energy expenditure (REE) is reportedly higher in adults with type 2 diabetes and impaired glucose tolerance, and is associated with insulin resistance (IR), independently of obesity. There is less information about these relationships in young children in whom obesity and diabetes are rising. The aim of this analysis was to investigate the relationships between REE, obesity and IR in young children. REE was measured by indirect calorimetry, fat-free mass (FFM) and fat mass (FM) by DEXA, and IR by HOMA in a single cohort of 172 prepubertal children at age 7.0 ± 0.3y. The measurements were repeated at ages 8y and 9y. The fat percentage of girls at 9y was substantially greater than that of boys (26.3% -v- 17.4%, p<0.0). REE was positively associated with FFM and FM at all time-points (all r > 0.32, all p< 0.002). Correlations at 7y and 8y between REE and IR after adjustment for body composition did not reach significance (all r< 0.2, p> 0.07). At age 9y, however, a weak positive correlation emerged between IR and REE independent of body composition in boys but not in girls (boys: r= 0.24, p= 0.01, girls: r= 0.02, p= 0.84) - REE was significantly higher in boys in the highest tertile of IR compared with the lowest tertile of IR, independently of body composition (1456 -v- 1355 kcal/day, p= 0.01). Insulin resistance is believed to limit weight gain. One mechanism may be a rise in REE. The failure of REE to rise with IR in girls, while it does in boys, may help to explain the greater fat percentage of girls at 9y.
- Publication
Diabetes, 2007, Vol 56, pA474
- ISSN
0012-1797
- Publication type
Academic Journal