We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MHC class I molecules co‐stimulate NK1.1 signaling and enhance Ca<sup>2+</sup> flux in murine NK cells.
- Authors
Ganesan, Sridharan; Höglund, Petter
- Abstract
Keywords: calcium flux; cross-linking; Ly49 receptors; MHC class I; NK cell EN calcium flux cross-linking Ly49 receptors MHC class I NK cell 2531 2534 4 10/07/21 20211001 NES 211001 Simultaneous triggering of NK1.1 and MHC class I on NK cells gives a higher Ca SP 2+ sp flux response compared to triggering the NK1.1 receptor alone. MHC class I molecules are not only ligands for inhibitory NK cell receptors, but may also inhibit NK cell function themselves [3-5]. GLO:BVO/01oct21:eji5164-fig-0001.jpg PHOTO (COLOR): 1 MHC class I cross-linking triggers Ca2+ flux in mouse NK cells and provides an additive stimulatory signal in combination with NK1.1. MHC class I molecules co-stimulate NK1.1 signaling and enhance Ca2+ flux in murine NK cells.
- Publication
European Journal of Immunology, 2021, Vol 51, Issue 10, p2531
- ISSN
0014-2980
- Publication type
Academic Journal
- DOI
10.1002/eji.202048709