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- Title
RP-HPLC AND HPTLC STABILITY INDICATING ASSAY METHODS FOR IVERMECTIN IN BULK AND TABLET DOSAGE FORM.
- Authors
Wani G. P.; Jadhav S. B.
- Abstract
Simple, rapid, precise, accurate RP-hPLc and hPTLc methods have been developed and validated for ivermectin in bulk and its marketed formulation. RP-hPLc method for drug was achieved on Grace c18 (250 mm X 4.6 ID, Particle size; 5 µ) column using mobile phase acetonitrile: 10 mM phosphate buffer (95:05 V/V) ph adjusted to 3 with o-phosphoric acid. Detection of drug was done at 245 nm. The retention time was found to be 5.83 min. hPTLc method for ivermectin was accomplished on a precoated silica gel aluminium plate 60F-254 (cAMAG Linomat 5), using toluene: methanol: glacial acetic acid (8:2:0.1 V/V/V) as a mobile phase. The densitometric scanning was performed at 245 nm which showed Rf 0.46 for ivermectin. The stress testing of the drug individually was carried out under acidic, alkaline, oxidation, photo-stability and thermal degradation conditions. The proposed methods were successfully applied for the determination of drug in bulk and its marketed formulation.
- Publication
Indian Drugs, 2018, Vol 55, Issue 3, p32
- ISSN
0019-462X
- Publication type
Academic Journal
- DOI
10.53879/id.55.03.11143