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- Title
ARTERIAL BLOOD GAS ABNORMALITIES AND THE RISK OF INTRAVENTRICULAR HEMORRHAGE OR NECROTIZING ENTERCOLITIS IN PRETERM NEONATES.
- Authors
Brown, Melissa K.; Hassen, Kasim; Poeltler, Debra; Brown, Vanessa; Pierce, Brianna; Patel, Dhruv; Rich, Wade; Katheria, Anup
- Abstract
Background: Changes in arterial carbon dioxide levels affect cerebral blood flow. Hypercapnia, hypocapnia, and acidosis have been linked with intraventricular hemorrhage (IVH) risk in preterm neonates. The objective of this analysis was to test the hypothesis that extremes of PaCO2 and acidosis during the first 3 days after birth are associated with adverse events such as intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC) in preterm neonates. Methods: A retrospective analysis was performed on 150 infants < 32 weeks GA, without congenital anomalies, who were part of a delayed cord clamping clinical trial between August 2014 and October 2015. Three infants without ABGs were excluded. All ABGs in the first 72 hours of life were included in the analysis. The means of the variables PaCo2 PaCO2 maximum, PaCO2 minimum, PaCO2 fluctuation (PaCO2 maximum-minimum & PaCO2 Standard Deviation), pH minimum, and Base Excess were analyzed with an unpaired student T-Test and logistic regression. Level of significance was set to < 0.01 to protect against false positives due to multiple comparisons. The study was reviewed by the Sharp IRB. Results: A total of 1341 samples were analyzed from 147 subjects, 9.3 ± 4.9 samples per subject. GA was 28 ± 2 weeks, BW was 1206 ± 394 grams. Minimum PaCO2 was not significant for any of the variables. The results are displayed in the table below. Conclusions: Infants with severe IVH had significantly lower mean values for minimum pH. Infants with the compound outcome of death/IVH had significantly higher values for mean and fluctuations in PaCO2. Disclosures: Wade Rich is a paid consultant with Windtree Therapeutics. Sponsored Research-None
- Publication
Respiratory Care, 2016, Vol 61, Issue 10, pOF43
- ISSN
0020-1324
- Publication type
Academic Journal