We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of UVB-Induced Serum Factor(s) in Suppression of Contact Hypersensitivity in Mice.
- Authors
Swartz, Rodney P.
- Abstract
Ultraviolet, 280-320 nm (UVB), irradiation of the shaved dorsal skin of mice results in suppression of the development of contact hypersensitivity (CHS) to antigens applied subsequently to a distant nonirradiated skin site. Serum from BALB/cAnNCr mice exposed to a single dose of UVB radiation (8.6 × 104 J/m2) was evaluated for its ability to induce suppression of CHS to 2-chloro-1,3,5-trinitrobenzene (TNCB), a contact allergen, after transfer to normal recipients. Serum from UVB-irradiated donors was capable of inducing immunosuppression only when collected and transferred within a restricted time period, i.e., approximately 2-6 h post irradiation, and at least 400 μl of serum per recipient was required. Serum from UVB-irradiated donors was sufficient to induce splenic suppressor cells in recipient mice.
- Publication
Journal of Investigative Dermatology, 1984, Vol 83, Issue 4, p305
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1111/1523-1747.ep12340434