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- Title
Depletion of Alcohol (Hexanol) Dehydrogenase Activity in the Epidermis and Jejunal Mucosa in Sjögren-Larsson Syndrome.
- Authors
Judge, Mary R.; Lake, Briand D.; Smith, Virpi V.; Besley, G. T. N.; Harper, John I.
- Abstract
Using a histochemical technique, we have demonstrated a consistent deficiency of alcohol (hexanol) dehydrogenase activity within the epidermis and jejunal mucosa of patients with Sjögren-Larsson syndrome. Biochemical assay of the fatty alcohol : NAD oxidoreductase activity in cultured fibroblasts and leukocytes from these patients showed deficient activities compared with controls. The histochemical and biochemical results are complementary, and the simpler histochemical method can be used reliably for initial screening of patients with ichthyosis whom a diagnosis of Sjögren-Larsson syndrome is suspected.
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, Issue 6, p632
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1111/1523-1747.ep12514294