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- Title
William Bayliss and the enduring fascination of myogenic tone.
- Authors
Wilson, Calum; McCarron, John G.; Lee, Matthew D.
- Abstract
The scientific observation we are highlighting is Sir William Maddock Bayliss's description of the response of excised blood vessels to changes in intravascular pressure (Bayliss, 1902). 'A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die' Max Planck, 1950 Given the pace of scientific progress over the seven decades since this much-quoted observation, it is clear that scientific progress does not require scientists with opposing views to die. Using what now seems to be primitive recording equipment (a smoked drum), Bayliss observed that a brief, step-wise increase in intravascular pressure caused a paradoxical decrease in the diameter of isolated blood vessel(s).
- Publication
Journal of Physiology, 2022, Vol 600, Issue 18, p4043
- ISSN
0022-3751
- Publication type
Academic Journal
- DOI
10.1113/JP282890