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Title
NF is enough of GAP.
Authors
Bollag, G.; McCormick, F.
Abstract
Discusses neurofibromatosis type 1 (NF1), a genetic disease characterized by benign and sometimes malignant tumors that originate in the neural crest. Identification of the gene which is defective in NF1 patients; Neurofibromin as a GTPase-activating protein (GAP) for the p21 ras proto-oncogene product that converts active GTP-bound p21 ras to its inactive GDP-bound state; Study by Basu, et al; More.