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Title
Towards a better aspirin.
Authors
Vane, John
Abstract
Discusses the implications of the crystal structure of the membrane protein prostaglandin H(2) synthase-1 on finding better aspirin-like drugs. Actions of the two known isoforms of cyclooxygenase; Oxidation of arachidonic acid to prostaglandin G(2); Cyclooxygenase active site; Consequences of the activation of the constitutive enzyme; Search for better non-steroid anti-inflammatory drugs.