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- Title
Chemoselective Peptide Ligation-Desulfurization at Aspartate.
- Authors
Thompson, Robert E.; Chan, Bun; Radom, Leo; Jolliffe, Katrina A.; Payne, Richard J.
- Abstract
The article presents a study of chemoselective peptide ligation-desulfurization to a protected β-mercapto aspartate (Asp) residue. It develops an scalable route to a protected β-mercapto Asp building block to facilitate rapid ligation to peptide thioesters. It suggests that the possibility of pH-dependent polar pathway could not be ruled out despite the consistency of the selective desulfurization reactions with the bond dissociation energies (BDEs).
- Publication
Angewandte Chemie, 2013, Vol 125, Issue 37, p9905
- ISSN
0044-8249
- Publication type
Academic Journal
- DOI
10.1002/ange.201304793