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- Title
Synthesis and Antimicrobial Activity of 5-(R<sup>1</sup>-benzyl)-2-(R<sup>2</sup>-benzylidenehydrazono)-3-(2-furylmethyl)Thiazolidin-4-ones.
- Authors
Tsyalkovsky, V. M.; Kutsyk, R. V.; Matiychuk, V. S.; Obushak, N. D.; Klyufinskaya, T. I.
- Abstract
3-Aryl-2-bromopropanoic acid esters react with furfurylthiosemicarbazones of benzaldehyde and 4-chlorobenzaldehyde to form 5-(R1-benzyl)-2-(4-R-benzylidenehydrazono)-3-furfuryl-4-thiazolidinones (R = H, 4-Cl; R1 = 4-Me, 4-F, 4-Cl). The antimicrobial activity of the synthesized compounds was studied, and it was established that only the compounds with R1 = Me are active. The replacement of methyl group by halogen results in the loss of antimicrobial activity.
- Publication
Pharmaceutical Chemistry Journal, 2005, Vol 39, Issue 5, p245
- ISSN
0091-150X
- Publication type
Academic Journal
- DOI
10.1007/s11094-005-0126-8