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- Title
Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives.
- Authors
El-Nezhawy, A. O. H.; El-Naem, S. I.; Galal, S. A.; El-Diwani, H. I.; Abdel Salam, O. M. E.; Baiomy, A. R.
- Abstract
Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3, 4, 11, 15 – 17, and 20 – 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds.
- Publication
Pharmaceutical Chemistry Journal, 2009, Vol 43, Issue 1, p25
- ISSN
0091-150X
- Publication type
Academic Journal
- DOI
10.1007/s11094-009-0234-y