We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis.
- Authors
Horii, Yasuhiro; Iwano, Masayuki; Hirata, Eiji; Shiiki, Hideo; Fujii, Yoshihiro; Dohi, Kazuhiro; Ishikawa, Hyoe
- Abstract
Mesangial proliferative glomerulonephritis (mesPGN) is histologically characterized by proliferation of mesangial cells (MC), suggesting the involvement of a growth factor for MC in the pathogenesis of mesPGN, We have previously shown that interleukin-6 (lL-6) induces proliferation of cultured rat mesangial cells, and urine samples from patients with IgA nephropathy contain high level of IL-6 activity. We have also demonstrated that transgenic mice carrying a human IL-6 genomic gene showed severe mesangial proliferation and matrix enlargement. Urinary samples of patients with lupus nephritis as well as IgA nephropathy contain significant IL-6 activity. Over a ten month follow-up, a positive correlation between the urinary IL-6 and pathological score was observed. Hence, measurement of urinary lL-6 can be used as a good indicator for monitoring IgA nephropathy and lupus nephritis. Using RT-PCR methods, lL-6 mRNA was detected in the glomeruli of renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis.
- Publication
Kidney International Supplement, 1993, Issue 39, pS-71
- ISSN
0098-6577
- Publication type
Academic Journal
- DOI
10.1111/1523-1755.ep15008951