We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Renal tubular epithelial and T cell interactions in autoimmune renal disease.
- Authors
Kelley, Vicki Rubin; Diaz-Gallo, Cristina; Jevnikar, Anthony M.; Singer, Gary G.
- Abstract
Interaction between epithelial cells and T cells may initiate autoimmune tissue destruction. Renal tubular epitheliai cells may participate in such immune interactions since they: (1) can be induced to express surface molecules which facilitate engagement with T cells; (2) secrete and express membrane bound cytokines; (3) are exposed to peptides from blood and the glomerular filtrate and are capable of processing these potentially immunogenic peptides. We have recently established T cell clones captured from the interstitium of MRL-lpr mice with lupus nephritis. These T cell clones are unique and are regulated by the Ipr gene. They express the α/β T cell receptor, and β cell markers, but do not display CD4 or CD8 on their surface. These T cell clones proliferate to renal tubular cells but not lo cells from other tissues and secrete IFN-γ which induces class II and ICAM-1 on renal tubular epithelial cells. Expression of class II and ICAM-1 induced by IFN-γ renders these epithelial cells capable of triggering T cell hybridomas to proliferate and secrete IL-2. Therefore, renal tubular epithelial cells are capable of processing and presenting antigen. This review will focus on the dynamic interaction of renal epithelial cells and T cells and discuss its importance in the initiation of autoimmune renal injury.
- Publication
Kidney International Supplement, 1993, Issue 39, pS-108
- ISSN
0098-6577
- Publication type
Academic Journal
- DOI
10.1111/1523-1755.ep15009012