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- Title
The liver as a site of T-cell apoptosis: graveyard, or killing field?
- Authors
Crispe, I. Nicholas; Dao, Tao; Klugewitz, Katja; Mehal, Wajahat Z.; Metz, Daniela P.
- Abstract
The liver is a site at which apoptotic CD8+ cells accumulate during the clearance phase of peripheral immune responses. Normal mouse liver contains an unusual mixture of lymphocytes in which natural killer (NK) and NK-T cells are abundant and apoptotic T cells are present, and we interpret these cell populations as, respectively, agents and targets of an intrahepatic T-cell trapping and killing mechanism. In support of this idea, direct perfusion of activated hyphocyte populations through the normal liver results in the selective retention of activated CD8+ T cells. T cells trapped in this manner undergo apoptosis in the liver. This mechanism could explain the importance of the liver in oral tolerance, the phenomenon of tolerance induced by portal vein infusion of antigenic cells, the tolerance to allogenic liver allografts, and the persistence of some liver pathogens including hepatitits C.
- Publication
Immunological Reviews, 2000, Vol 174, Issue 1, p47
- ISSN
0105-2896
- Publication type
Academic Journal
- DOI
10.1034/j.1600-0528.2002.017412.x