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- Title
Efficacy of Very Low Dose Intravenous Lidocaine in Preventing Cough and Sore Throat after Awakening from General Anesthesia: A Randomized Controlled Trial.
- Authors
Munjupong S.; Malaithong W.; Mansumruatkan T.; Chantrapannik E.; Oofuvong M.
- Abstract
Objective: To evaluate the minimal dose of intravenous lidocaine (0.25 mg/kg) administered before extubation to prevent post-operative cough and sore throat. Materials and Methods: The present study employed a prospective double-blinded randomized, control trial. Eighty-five patients scheduled for elective surgery were randomized to receive an intravenous lidocaine bolus of 0.25 mg/kg (treatment group), or 0.5 mg/kg (control group) at the end of anesthesia. The severity of cough and post-operative sore throat were evaluated by a blinded anesthesiologist. Results: Forty-two patients were assigned to the treatment group and 43 patients to the control group. According to the non- inferiority margin in the present study of 10% compared with the high-dose group, the coughing rate after extubation in the 0.25 mg/kg group was 42.9%, and in the 0.5 mg/kg group was 23.3%, a difference of coughing rate between both groups of 19.6% (95% CI 3.17% to 36.03%, p-value for non-inferiority=0.998). Conclusion: The treatment group (0.25 mg/kg of lidocaine) had less effective medicine than the control group (0.5 mg/kg of lidocaine) for preventing cough after extubation as well as the severity of cough.
- Publication
Journal of the Medical Association of Thailand, 2019, Vol 102, Issue 9, p1009
- ISSN
0125-2208
- Publication type
Academic Journal