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- Title
Inflammatory response to different endodontic irrigating solutions.
- Authors
Tanomaru Filho, M.; Leonardo, M. R.; Silva, L. A. B.; Aníbal, F. F.; Faccioli, L. H.
- Abstract
Abstract Tanomaru Filho M, Leonardo MR, Silva LAB, Aníbal FF, Faccioli LH. Inflammatory response to different endodontic irrigating solutions. International Endodontic Journal , 35 , 735–739, 2002. Aim The aim of this study was to evaluate the inflammatory response to irrigating solutions injected into the peritoneal cavity of mice. Methodology Sixty mice received intra-peritoneal injections of 0.3 mL of 0.5% sodium hypochlorite, 2.0% chlorhexidine digluconate or phosphate buffered saline (PBS, control). Five animals of each group were sacrificed at 4, 24, 48 h and 7 days after the injection. Liquid from the peritoneal cavity of each animal was collected for the total and differential counting of inflammatory cells and protein leakage. Results The 0.5% sodium hypochlorite solution group had greater migration of neutrophils and mononuclear cells to the peritoneal cavity from 48 to 168 h (P < 0.05). There was a significant increase in protein leakage to the peritoneal cavity after 4 up to 48 h in the 0.5% sodium hypochlorite group compared to the control group. Protein leakage was similar in all groups at 168 h. The 2.0% chlorhexidine group had similar results to the control group at all time periods. Conclusions The 0.5% sodium hypochlorite solution induced an inflammatory response, however, the 2.0% chlorhexidine digluconate solution did not induce a significant inflammatory response.
- Publication
International Endodontic Journal, 2002, Vol 35, Issue 9, p735
- ISSN
0143-2885
- Publication type
Academic Journal
- DOI
10.1046/j.1365-2591.2002.00544.x