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- Title
Venlafaxine for the Control of Hot Flashes: Results of a Longitudinal Continuation Study.
- Authors
Barton, Debra; Vasseur, Beth La; Loprinzi, Charles; Novotny, Paul; Wilwerding, Mary Beth; Sloan, Jeff
- Abstract
Purpose/Objectives: To evaluate the intermediate term efficacy and toxicity of the use of venlafaxine for the control of hot flashes. Design: An open-label continuation phase study following a double-blind, randomized, placebo-controlled clinical trial that tested three doses of venlafaxine for the control of hot flashes. Setting: North Central Cancer Treatment Group institutions. Sample: 102 postmenopausal women. Methods: Women could titrate venlafaxine to optimum efficacy while recording daily hot flash counts and weekly toxicity information. Main Research Variables: Hot flash frequency, hot flash score. Findings: The reduction in hot flashes previously reported in the randomized study phase was maintained during the open-label study. Toxicity did not appear to increase over time. Conclusions: The data from this study provides evidence that venlafaxine has intermediate term efficacy and good tolerability as a treatment for hot flashes. Implications for Nursing Practice: Nurses can inform symptomatic women that an effective nonhormonal alternative exists to control their hot flashes.
- Publication
Oncology Nursing Forum, 2002, Vol 29, Issue 1, p1
- ISSN
0190-535X
- Publication type
Academic Journal
- DOI
10.1188/02.ONF.33-40