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- Title
SYNTHESIS AND MOLECULAR DOCKING STUDIES ON DIFFERENT THIOZOLIDINONE DERIVATIVES OF BENZILIC ACID.
- Authors
SUDHA, R.; DEVI, P. BRINDHA; NITHYA, G.; PRIYATHARESINI, P. INDRA
- Abstract
Viral diseases continue to cause serious morbidity and mortality worldwide. For several virus infections, no antiviral medications are presently available especially for Covid-19. There is a clear need for new antiviral agents with new mechanisms of action or broad-spectrum activity, to face the issues of drug-resistant mutant viruses or emerging and neglected viruses. The benzilic acid thiazolidinone derivatives were prepared by reaction of alkyl/arylthiosemicarbazides with 2-bromopropionate in the presence of anhydrous sodium acetate in absolute ethanol from benzilic acid hydrazide. Compounds, which consist of (-C=N-N-) - the two interlinked nitrogen atoms, have been found to possess many biological activities. Viral diseases continue to cause serious morbidity and mortality worldwide. For several virus infections, no antiviral medications are presently available especially for Covid-19. There is a clear need for new antiviral agents with new mechanisms of action or broad-spectrum activity, to face the issues of drug-resistant mutant viruses or emerging and neglected viruses. The present work is an extension of our ongoing efforts toward developing promising biologically active agents using a hybrid pharmacophore approach.
- Publication
Oxidation Communications, 2022, Vol 45, Issue 2, p238
- ISSN
0209-4541
- Publication type
Academic Journal