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- Title
Synthesis, Characterization and Cytotoxic Effect of Some New Thiazolyl Hydrazone Derivatives of 1-Indanone.
- Authors
Nazim, Urooj; Narayanan, Silpa; Ali, Mohsin; Khan, Khalid Mohammed; Ali, Basharat; Li, Jonathan; Chen, Zhe-Sheng; Ahmed, Mansoor; Yang, Dong-Hua
- Abstract
Summary: In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25±0.02 to 5.04±0.2 µM. On the other hand all the compounds didn't show cytotoxic activity against other forms of human cancer cells.
- Publication
Journal of the Chemical Society of Pakistan, 2021, Vol 43, Issue 2, p244
- ISSN
0253-5106
- Publication type
Academic Journal
- DOI
10.52568/000564