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- Title
Oxidative Decomposition of Quercetin in Presence of Ruthenium(III).
- Authors
Zahirović, A.; Turkušić, E.; Kahrović, E.
- Abstract
Since NAMI-A (Imidazolium tetrachloro(dimethylsulphoxide- S)(imidazole)ruthenate(III)) and KP1019 (Indazolium tetrachlorobis(indazole) ruthenate(III)) entered clinical trials neither one of substantially new ruthenium based complex showed promising biological properties. In light of persuasive ruthenium potential to improve activity of biologically active ligands and positive health effects of flavonoids, we aimed to investigate possibilities of ruthenium to bind quercetin, since there are no described efforts on synthesis of ruthenium flavonoid (quercetin) complexes. We investigated reaction of quercetin with ruthenium trichloride hydrate under mild reaction conditions applying wet-synthesis and liquid assisted mechanochemical ball grinding. Reaction conditions regarding atmosphere, solvent, temperature, molar ratio and coordinating nature of anion were systematically changed. Reaction products were separated by column chromatography and fractions were selectively analyzed. Ruthenium containing species were analyzed by vibrational and electronic spectroscopy, MALDI-TOF/TOF mass spectrometry, elemental analysis, thermogravimetry and conductometry. Furthermore HPLC-DAD was applied to confirm complexity of reaction mixtures. In all cases we found that ruthenium induced oxidative decomposition of quercetin and that 2,3,4- trihydroxybenzoic acid was bound to ruthenium(II) in neutral or anionic complex species. Results clearly suggest that new design of synthetic approach toward ruthenium-quercetin complexes needs to be utilized.
- Publication
Bulletin of the Chemists & Technologists of Bosnia & Herzegovina / Glasnik Hemičara i Tehnologa Bosne i Hercegovine, 2016, p86
- ISSN
0367-4444
- Publication type
Academic Journal