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- Title
Use of Fluorescent Light in Detecting Malignant and Premalignant Lesions in the Oral Cavity: A Prospective, Single-Blind Study.
- Authors
Marzouki, Hani Z.; Thien Tuong Vi Vu; Ywakim, Rania; Chauvin, Peter; Hanley, James; Kost, Karen M.
- Abstract
Objective: To determine the usefulness of the VELscope in detecting malignant and premalignant oral cavity lesions. Study Design: Prospective clinical study. Setting: Head and neck oncology clinic at an academic tertiary care centre. Subjects and Methods: Eighty-five patients with a history of smoking, alcohol use, and/or head and neck cancer were recruited into the study. The VELscopewas used to examine patients' oral cavities after a clinical examination. Biopsieswere then taken from suspicious areas. Results: Of the 85 patients included in the study, 33 underwent biopsies prompted by a clinical examination, the VELscope, or both. Biopsy results that showed invasivemalignancy or dysplasiaswere considered positive. Five positive biopsies for premalignant lesions were detected only by the VELscope and were not visible on clinical examination. On the other hand, only one positive biopsy for a premalignant lesion was detected by the clinical examination only and not seen on the VELscope. Seven positive biopsies were detected by bothmethods. This indicates that the diagnostic yield froma regular examination was 47%(95% CI23-72) and that the diagnostic yield from the addition of the VELscope was an additional 31% (95% CI 11-59). Sensitivity and specificity for the VELscope were 92% and 77%, respectively. Conclusion: The Velscope may add sensitivity to the clinical examination and be a useful adjunct in high-risk patients.
- Publication
Journal of Otolaryngology -- Head & Neck Surgery, 2012, Vol 41, Issue 3, p164
- ISSN
0707-7270
- Publication type
Academic Journal
- DOI
10.2310/7070.2012.00022