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- Title
Graft versus leukemia (GVL) in the therapy of acute lymphoblastic leukemia (ALL).
- Authors
Appelbaum, Frederick R.; Appelbaum, F R
- Abstract
The ability of T cells that accompany or develop from transplanted allogeneic marrow to eradicate leukemia has been repeatedly demonstrated in animal models. Whether a similar graft-versus-leukemia effect exists in humans who have received transplants for acute lymphoblastic leukemia can be addressed by five different clinical observations: comparisons of autologous versus allogeneic transplantation, comparisons of syngeneic versus allogeneic transplantation, examination of relapse rates in allogeneic recipients who do or do not develop GVHD, the impact of T-cell depletion on relapse rates, and the results of donor lymphocyte infusions to treat posttransplant relapse. The bulk of available evidence supports the view that a potent GVL effect exists in patients treated for ALL. These results provide a strong rationale for efforts to develop techniques to further capitalize on the GVL effect.
- Publication
Leukemia (08876924), 1997, Vol 11, pS15
- ISSN
0887-6924
- Publication type
Academic Journal