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- Title
Structure, mapping, and expression of human SOX18.
- Authors
Pennisi, David J.; James, Kristy M.; Hosking, Brett; Muscat, George E. O.; Koopman, Peter
- Abstract
The article informs about structure, mapping, and expression of human SOX18 genes. SOX genes are found throughout the animal kingdom and encode a highly conserved family of transcription factors involved in a wide range of developmental processes. Several SOX genes have been implicated in inherited human disorders: SRY in male-to-female sex reversal and gonadal dysgenesis; SOX9 in the skeletal dysmorphogenesis syndrome campomelic dysplasia. Furthermore, targeted disruption in mice has demonstrated vital roles for Sox4 in cardiac development, Sox9 in chondrogenesis and Sox1 in lens development.
- Publication
Mammalian Genome, 2000, Vol 11, Issue 12, p1147
- ISSN
0938-8990
- Publication type
Academic Journal
- DOI
10.1007/s003350010216