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- Title
A new clinicopathological entity of IgG4-related autoimmune disease.
- Authors
Kamisawa, Terumi; Funata, Nobuaki; Hayashi, Yukiko; Eishi, Yoshinobu; Koike, Morio; Tsuruta, Kouji; Okamoto, Atsutake; Egawa, Naoto; Nakajima, Hitoshi
- Abstract
<bold>Background: </bold>Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.<bold>Methods: </bold>To investigate the pathophysiology of AIP, we immunohistochemically examined the pancreas and other organs in eight patients with AIP, and in controls, using anti-CD4-T and CD8-T cell subsets, as well as IgG4 antibodies.<bold>Results: </bold>In AIP patients, severe or moderate infiltration of IgG4-positive plasma cells associated with CD4- or CD8-positive T lymphocytes was detected in the peripancreatic tissue (6/6), bile duct (8/8), gallbladder (8/8), portal area of the liver (3/3), gastric mucosa (5/7), colonic mucosa (2/2), salivary glands (1/2), lymph nodes (6/6), and bone marrow (2/2), as well as in the pancreas (8/8). There were few IgG4-positive plasma cells at the same sites in controls.<bold>Conclusions: </bold>These results suggest that AIP is not simply pancreatitis but that it is a pancreatic lesion involved in IgG4-related systemic disease with extensive organ involvement. We propose a new clinicopathological entity, of a systemic IgG4-related autoimmune disease in which AIP and its associated diseases might be involved. Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
- Publication
Journal of Gastroenterology, 2003, Vol 38, Issue 10, p982
- ISSN
0944-1174
- Publication type
Academic Journal
- DOI
10.1007/s00535-003-1175-y