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- Title
Resting energy expenditure in female children with cystic fibrosis - effect of puberty.
- Authors
Allen, J. R.; Barclay, A.; Prior, R.; Byler, E.; Gruca, M. A.; Van Asperen, P.; Cooper, P.; Gaskin, K. J.
- Abstract
Background - The female gender has been shown to be one of the contributing factors to elevated resting energy expenditure (REE) in children with cystic fibrosis (CF), but it is not known if this effect is influenced by pubertal development. Objective - The aim of this study was to determine the effect of puberty on REE, in females with CF. Design - Children with CF were recruited from the CF clinic at the Children's Hospital at Westmead and controls were recruited through families and friends of hospital staff. All children were aged 5-18 years and were generally well. REE, anthropometry and self-reported pubertal staging were measured in 38 children with CF (27 pre-menarche, 11 post-menarche) and 63 controls (42 pre-menarche, 21 post-menarche) in an outpatient setting. The post-menarche group were all measured in the follicular stage of their menstrual cycle. Outcomes - Females with CF had a higher REE than controls (108.4 ± 11.1% of predicted from controls P<0.001). However this increase in REE was only significant for pre-menarche females (109.7 ± 12.1% of predicted from controls, P<0.005) compared with a median 104.0% (92.1, 116.6%) of predicted from control data (P=0.06) for post-menarche females. There was no significant difference in REE (% predicted from controls) between pre- and post-menarche children with CF (P=0.12). Conclusions - Pre-menarche females with CF had raised REE in contrast with post-menarche females but this finding must be confirmed with further numbers of post-menarche females. This study implies that young females with CF may need more intensive dietary management, due to raised REE, in order to maintain growth, nutritional status and possibly improve survival.
- Publication
Asia Pacific Journal of Clinical Nutrition, 2004, Vol 13, pS41
- ISSN
0964-7058
- Publication type
Academic Journal