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- Title
ROLE OF RED GRAPE EXTRACT AGAINEST NICOTINE INDUSED OXIDATIVE STRESS IN THE HEART TISSUE OF MALE ALBINO RAT WITH REFERENCE TO AGING.
- Authors
Subahan, M.; Basha, K. Khalindar; Sivasankar, R.; Suresh, K.; Chennaiah
- Abstract
Red grape (Vitis vinifera.L) presumably originates from Western Asia, from the area between the Caspian Sea region and Asia Minor, where also its cultivation seems to have begun . These archeological finds, up to this day the oldest documentation for the use of grape vine products in human culture, were dated to 3500-2900 B.C. Red grape is commercial juice products from Concord grapes have been applied in medical research studies, showing potential benefits against the diseases. Nicotine as most biologically active chemical in tobacco smoke. Nicotine has been reported to induce changes both in vivo and in vitro. Pathogen free, Wistar strain male albino rats were used in the present study. rats were divided into 4 groups of six in each group i) Normal Control (NC) (Control rats received 0.9% saline) ; ii) Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months ); iii) Red Grape extract treated (RGEt) (red grape extract 50mg/kg body weight (after the standardization) via orogastric tube for a period of 2 months. ); IV)) Nicotine + Red Grape (Nt+RGEt) (Rats were received the nicotine at a dose as mentioned for Group II through subcutaneous injection and, red grape extract as mentioned above Group III via orogastric tube for a period of 2 months). The animals were sacrificed after 24 hrs after the last treatment by cervical dislocation and isolated the heart tissue such as the activites of the levels of Total Carbohydrates, Glycogen and Total Free Amino Acids, were decreased in nicotine treated rats in the heart tissue and increase was observed in the combination (Nt+RGEt),but at 50 mg/kg body weight found to be more effective. This results stating that red grape extract treated rats were beneficial, especially for the nicotine subjects to improve the carbohydrate metabolic profiles.
- Publication
Bulletin of Pure & Applied Sciences-Zoology, 2013, Vol 32A, Issue 2, p45
- ISSN
0970-0765
- Publication type
Academic Journal