We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Moringa Oleifera Leaf Extract on Oxidative Stress and Theca Cell in Polycystic Ovary Syndrome Model with Insulin Resistance.
- Authors
Purbawaning Wulandari, Lisa; Santoso, Budi; Purwanto, Bambang; Miftahussurur, Muhammad; Yanuar Annas, Jimmy; Budiono
- Abstract
Background: The use of Moringa oleifera as an antioxidant should be investigated as an alternative treatment of oxidative stress and follicular refinement in PCOS with insulin resistance. Purpose: We aimed to prove the effect of Moringa oleifera leaf extract in various dosages to decrease the malondialdehyde levels and theca cell thickness of PCOS female rat with insulin resistance. Method: Three month old Rattus norvegicus stran wistar rat weighing 100-130 grams were divided into 5 groups (n = 8). PCOS model obtained by giving injection of testosterone propionate for 28 days, followed by metformin therapy and Moringa oleifera leaf extract at 250 and 500 mg/KgBW for 14 days. Then, we analyzed levels of malondialdehyde in the blood and the thickness of theca cell. Results: Malondialdehyde levels in the PCOS control group (5.694±1.464) increased significantly (p <0.05) compared to the normal controls (1.939 ±0.341). Leaf extract Moringa oleifera 500 mg/KgBW (1.982±0.383) showed a significant decrease (p <0.05) to malondialdehyde levels compared to the PCOS control group. Examination of ovarium histology showed that leaf extract Moringa oleifera 500 mg/KgBW (0.931±0.457) significantly decreased the thickness of theca cells (p <0.05) compared to the PCOS control group. Conclusion: Moringa oleifera leaf extract as an antioxidant proven to decrease the malondialdehyde levels and the thickness of theca cell of the female rat model of PCOS.
- Publication
Medico-Legal Update, 2021, Vol 21, Issue 2, p744
- ISSN
0971-720X
- Publication type
Academic Journal
- DOI
10.37506/mlu.v21i2.2771