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- Title
EFFECT OF LITHIUM CARBONATE ON CHROMOSOMAL ABERRATIONS AND MICRONUCLEI IN WHITE MICE.
- Authors
Khalaf, Sarab Dalaf; Sadeq, Wagdi Sabeeh
- Abstract
The development of modern technology and the growing industrial age have led to a more widespread occurrence of occupational diseases related to a variety of toxic metals, especially because some of them are carcinogenic. Lithium has been used extensively in the treatment of certain neuropsychiatric disorders.In our current study, the genotoxicity of Lithium carbonate was evaluated in mouse bone marrow cells using the micronucleus (mni) test, chromosome aberrations in bonemarrow cells. Lithium carbonate was administered to whit mice by gavage in doses of 300, 600 and 900 mg/kg.b wt and used Retinoic acid as the positive control (0.001 mg/kg. bwt.) intrapretonial injection. The results of current study shows that three experimental doses of Lithium carbonate 300, 600, 900 mg/kg. bwt. induced a significant increase p ≤ 0.05 in the frequency of MN(11.4±1.080, 1608±1.080 and 37.00±1.080) compared with the negative control. Significant increase p ≤ 0.05 in means of total numerical structural chromosome aberrations (1.00 ± 0.48, 2.00 ± 0.48 and 2.00 ± 0.48) and in structural chromosome aberrations (10.2± 0.84, 13.2± 0.84 and 15.6± 0.84) compared with of negative control in bone marrow. These results propose that Lithium carbonate has genotoxic potential in vivo tests. Our study indicate that lithium carbonate is good candidate for further in vivo therapeutic trials.
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, p4237
- ISSN
0972-5075
- Publication type
Academic Journal