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- Title
EFFECT OF SODIUM FLUORIDE, GALLIC ACID, N-ACETYLCYSTEINE AND THEIR COMBINATION ON LIPID AND PROTEIN PROFILE IN ADULT MALE RATS (PART-I).
- Authors
Jaddoua, Haneen B.; Khudair, Khalisa K.
- Abstract
This study was designed to investigate the ameliorative role of gallic acid (GA) and N-acetylcysteine (NAC) in reducing deleterious effect of sodium fluoride (NaF) on lipid and protein profile in adult male rats. Thirty (30) adult male rats were randomly and equally divided into five groups (six animals in each groups) they have handled daily for 60 days, as follows: control group (C), received tap water only. (T1), received 100ppm of NaF in drinking tap water, animals in proceeding groups were given in addition to NaF in drinking water the following: intraperitoneal (i/p) injection of 150 mg/kg/day/ of GA(T2 group), oral administration 25 mg/kg/day/of NAC (T3 group), while the combination of GA and NAC were given to animal in group (T4). In the same previous mentioned doses and method of administration. Fasting blood sample were collected by cardiac puncture technique at the beginning and the end of the experiment and serum were collected for estimation of serum lipid profile and protein profile. The results showed that administration NaF (T1group) caused a case of dyslipidemia manifested by significant elevation in serum concentration of triglyceride (TAG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) with significant decrease in serum high density lipoprotein-cholesterol (HDL-C) concentrations; changes in protein profile: significant decrease in serum total protein, albumin and globulins concentration. The current result also recorded that i/p injection of GA and orally administrated of NAC alone or combination of both to NaF exposed animals caused amelioration of all previously estimated parameters.
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 2, p3659
- ISSN
0972-5075
- Publication type
Academic Journal