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- Title
Chronic Anxiolytic Effect of Aqueous Extract of Terminalia chebula (AETC) in Rats.
- Authors
Shekar, R. Chandra; Manohar, V. R.; Rao, S. N.
- Abstract
components. Anxiety is considered to be a normal reaction to stress. When anxiety becomes excessive, it may fall under the classification of an anxiety disorder. Benzodiazepines (BZDs) are the major class of compounds used in anxiety and they remain the most commonly prescribed treatment for anxiety. Long-term uses of BZDs cause many adverse psychological and physical effects. In the present study, we have attempted to evaluate the anxiolytic activity of Aqueous Extract of Terminalia chebula (AETC) by Elevated plus Maze model in rats. The rats weighing 150-200gm were divided into 5 groups containing 6 animals for each dose and were housed for 10 days prior to testing. For chronic study, the control (1% Gum acacia), test drug AETC (9, 18 and 36mg/ kg) and standard drug Diazepam (1.0mg/kg) were administered orally for 10 days. One hour after oral administration of the drugs / vehicle on 10th day the experiment was conducted by Elevated Plus Maze. The results suggest that, behavioral disinhibitory effects of AETC exhibited anxiolytic activity at the dose of 18mg/kg comparable to diazepam.
- Publication
Drug Invention Today, 2012, Vol 4, Issue 9, p447
- ISSN
0975-7619
- Publication type
Academic Journal