We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypolipidemic of ethanolic extract of Salam bark (Syzygium polyanthum (Wight) Walp.) from Indonesia (Preclinical study).
- Authors
Sutrisna, Em; Nuswantoro, Yoga; Said, Robbi Fatqurahman
- Abstract
The aim of this research to evaluate the effect of 70% ethanol extract of Salam bark (Syzygium polyanthum (Wight) Walp.) ethanolic extract of Salam bark (EESB) from Indonesia toward blood cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in male rats Wistar strain. Materials and Methods: This study was a preclinical experimental study with a pre- and post-test with control group design. A total of 25 white male rats Wistar strain were divided into five groups with simple random sampling. The groups were negative control (aquadest), positive control (simvastatin 0.2 mg/200 g bw/day), dose I (0.36 g/200 g bw/day), dose II (0.72 g/200 g bw/day), and dose III (1.44 g/200 g bw/day). Blood cholesterol, triglyceride, LDL, and HDL levels were measured before and after applying treatment. This study was held for 15 days and data were analyzed by one-way ANOVA test followed by least significant difference test and Kruskal-Wallis followed by Mann-Whitney test. Results: The 70% EESB (S. polyanthum (Wight) Walp.) at dosage of 0.72 and 1.44 g/200 g bw/day can decrease blood cholesterol; triglyceride and LDL levels (P < 0.05), meanwhile, the extract at dosage of 0.36, 0.72, and 1.44 g/200 g bw/day can increase serum HDL levels (P < 0.05). Conclusions: The 70% EESB (S. polyanthum (Wight) Walp.) decreases the serum cholesterol, triglyceride, LDL, and increase HDL levels significantly in hypercholesterolemia male rats Wistar strain.
- Publication
Drug Invention Today, 2018, Vol 10, Issue 1, p55
- ISSN
0975-7619
- Publication type
Academic Journal