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- Title
Remineralizing effect of zinc reinforced synthetic nano-hydroxyapatite on caries-like lesion in human permanent teeth - An in vitro study.
- Authors
Elumalai, Maheswari; Doraikannan, Sri Sakthi; Indiran, Meignana Arumugham; Rathinavelu, Pradeep Kumar
- Abstract
Introduction: Dental caries is among the most common chronic disease worldwide. A number of research projects are now focusing on the development of remineralizing agents to cease the progression of initial dental caries. Synthetic nano-hydroxyapatite (NHA) has the same physicochemical properties as those of apatite in the enamel. It shows strong affinity to the tooth and can strongly adsorb on enamel surfaces. Zinc is a trace element of valuable importance in the oral cavity. Zinc and synthetic NHA has the potential to reduce demineralization and promote remineralization of incipient caries lesion. Aim: This study aims to evaluate and compare the remineralizing effect of synthetic NHA and zinc reinforced synthetic NHA on dental caries-like lesion in extracted human permanent teeth. Materials and Methods: In this in vitro study, 21 maxillary premolars extracted for orthodontic reasons were included in the study. Synthetic NHA was synthesized using calcium hydroxide and orthophosphoric acid. There are three groups, the first group for demineralized teeth specimen, the second group for 10% synthetic NHA solution, and the third group - zinc reinforced hydroxyapatite solution as treatment agents. Enamel window formation of 4 mm (length) × 4 mm (width) was created in teeth specimen. Initial enamel lesion was prepared with an acidic buffer followed by tooth specimens are subjected to pH cycling. Analysis of caries lesion depth after demineralization and remineralization of tooth specimens was done using polarized light microscope. Results: The mean dental caries lesion depth in demineralized solution group was 160 ± 32.6. In this study, the mean dental caries lesion depth in 10% synthetic NHA solution group and zinc reinforced synthetic NHA was 135.49 µm and 111.78 µm. Conclusion: Synthetic NHA has a remineralizing effect due to deposition of calcium phosphate ions in the porosities of demineralized area. The remineralizing potential of zinc reinforced synthetic NHA was found to be higher than synthetic NHA. Zinc reinforced synthetic NHA showed an additive remineralizing potential compared to synthetic NHA.
- Publication
Drug Invention Today, 2018, Vol 10, p3364
- ISSN
0975-7619
- Publication type
Academic Journal