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- Title
Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis.
- Authors
Basutkar, Roopa Satyanarayan; Tsundue, Tenzin; Siva, Hema; Rose, Anju; Ponnusankar, Sivasankaran
- Abstract
Recent studies exhibit low Vitamin D levels and iron deficiency anemia condition co-exist, but evidence on the impact of vitamin D supplementation on iron deficiency anemia is lacking. The objectives of the review were to estimate the efficacy of vitamin D supplementation on patients with iron deficiency anemia. This review included the Randomized Controlled Trials from PubMed, IndMed and Cochrane Database of Systematic Reviews. Trials presenting vitamin D supplementation with control groups administered placebo and published in a peer-reviewed journal were considered eligible. Four trials were included for the primary outcome analysis. Vitamin D supplementation had no statistically significant impact on the outcomes of Hemoglobin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} and Serum Ferritin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} However, there was a statistically significant impact for serum Vitamin D levels by supplementation of vitamin D {p<0.00001; MD 17.28, 95% confidence interval (CI) 5.64 to 28.92}. As the results depicted in this review are inconclusive, further randomized controlled studies are required to strongly conclude whether supplementation of vitamin D improves iron deficiency.
- Publication
Systematic Reviews in Pharmacy, 2019, Vol 10, Issue 1, p1
- ISSN
0975-8453
- Publication type
Academic Journal
- DOI
10.5530/srp.2019.1.1